Abstract |
In this retrospective study we report the results of treatment with clofibrate during at least 7 years in 9 patients with severe type III hyperlipoproteinemia. Initial treatment consisted of a diet, restricted in fat and calories, because of insufficient response additional therapy with 2 g clofibrate daily was given. Serum cholesterol decreased significantly from 14.3 +/- 4.4 mmol/l (mean +/- SD), on diet therapy, to average annual values ranging from 9.0 +/- 4.9 to 7.9 +/- 2.0 and serum triglycerides decreased significantly from 5.6 +/- 1.9 to average annual values from 3.8 +/- 1.8 to 2.0 +/- 0.7, despite a slight gain in bodyweight. Serious side-effects did not occur. After several years of treatment with clofibrate the drug was withdrawn temporarily. Serum lipids increased significantly in all patients to a level, not different from that before the start of drug therapy. It is concluded that clofibrate is a strong hypolipidemic drug for the treatment of type III hyperlipoproteinemia, which does not lose efficacy even after 7 years of use.
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Authors | P M Stuyt, P N Demacker, A Van't Laar |
Journal | Atherosclerosis
(Atherosclerosis)
1981 Nov-Dec
Vol. 40
Issue 3-4
Pg. 329-36
ISSN: 0021-9150 [Print] Ireland |
PMID | 7332612
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Body Weight
- Clofibrate
(adverse effects, therapeutic use)
- Female
- Humans
- Hyperlipoproteinemia Type III
(drug therapy)
- Lipids
(blood)
- Male
- Middle Aged
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