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Amino acid conferred protection against melphalan: interference with leucine protection of melphalan cytotoxicity by the basic amino acids in cultured murine L1210 leukemia cells.

AuthorsD T Vistica, J N Toal, M Rabinovitz
JournalMolecular pharmacology (Mol Pharmacol) Vol. 14 Issue 6 Pg. 1136-42 (Nov 1978) ISSN: 0026-895X [Print] United States
PMID732811 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Amino Acids
  • Aminobutyrates
  • Culture Media
  • Guanidines
  • Arginine
  • Leucine
  • Melphalan
Topics
  • Amino Acids (pharmacology)
  • Aminobutyrates (pharmacology)
  • Animals
  • Arginine (analogs & derivatives, pharmacology)
  • Cell Survival (drug effects)
  • Cells, Cultured
  • Culture Media
  • Drug Antagonism
  • Guanidines (pharmacology)
  • Leucine (pharmacology)
  • Leukemia L1210 (drug therapy, metabolism)
  • Melphalan (metabolism, pharmacology)
  • Mice
  • Structure-Activity Relationship
  • Time Factors

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