Skin reactions to a urea-containing cream.

Abstract	Patch tests with a cream (Calmuril) containing 10% urea were performed on 79 patients with eczematous skin disease; seven (9.9%) had positive tests. Patch tests with the ingredients of the cream were negative. It is suggested that the positive patch test reactions are toxic, due to hypertonicity and acidity of the cream.
Authors	M Cramers, J Thormann
Journal	Contact dermatitis (Contact Dermatitis) Vol. 7 Issue 4 Pg. 189-91 (Jul 1981) ISSN: 0105-1873 [Print] England
PMID	7326922 (Publication Type: Journal Article)
Chemical References	Dermatologic Agents Drug Combinations Lactates lactic acid, urea drug combination Lactic Acid Urea
Topics	Adolescent Adult Aged Dermatitis, Contact (etiology) Dermatologic Agents (adverse effects) Drug Combinations (adverse effects) Drug Hypersensitivity Female Humans Lactates (adverse effects) Lactic Acid Male Middle Aged Patch Tests Urea (adverse effects)

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