Gaba-antagonists alter spatial summation in receptive field centres of rod- but not cone-drive cat retinal ganglion Y-cells.

Abstract

1. When Y-type cat retinal ganglion cells were driven by cones, the i.v. administration of the GABA-antagonist picrotoxin failed to alter receptive field centre size. 2. This result is in marked contrast to our previous finding that when Y-cells were driven by rods, GABA-antagonists led to specific and reversible changes in centre size. 3. These results taken together suggest that for centre signals of Y-cells, the rod and cone pathways are pharmacologically distinct.

• Authors: A W Kirby, D E Schweitzer-Tong
• Journal: The Journal of physiology (J Physiol) Vol. 320 Pg. 303-8 (Nov 1981) ISSN: 0022-3751 [Print] England
• PMID: 7320938 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Picrotoxin

Topics

• Animals
• Cats
• Dark Adaptation
• Neurons (drug effects, physiology)
• Photoreceptor Cells (physiology)
• Picrotoxin (pharmacology)
• Retina (cytology, drug effects)
• Visual Fields (drug effects)