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Enzyme studies with human and hen autopsy tissue suggest omethoate does not cause delayed neuropathy in man.

Abstract
Levels of acetylcholinesterase and neurotoxic esterase were measured in brain autopsy material. In tissue from a fatal human poisoning and from hens given 4-8 x unprotected LD50 AChE was highly inhibited and neurotoxic esterase uninhibited. The findings correlate with the inhibitory power of omethoate against these enzymes in vitro. It is concluded that omethoate has negligible potential to cause delayed neuropathy and a published report of human neuropathy due to omethoate is criticised.
AuthorsM Lotti, S D Ferrara, S Caroldi, F Sinigaglia
JournalArchives of toxicology (Arch Toxicol) Vol. 48 Issue 4 Pg. 265-70 (Nov 1981) ISSN: 0340-5761 [Print] Germany
PMID7316761 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Insecticides
  • dimethoxon
  • Acetylcholinesterase
  • Butyrylcholinesterase
  • Dimethoate
Topics
  • Acetylcholinesterase (metabolism)
  • Adult
  • Animals
  • Brain (enzymology)
  • Butyrylcholinesterase (metabolism)
  • Chickens
  • Dimethoate (analogs & derivatives, poisoning, toxicity)
  • Female
  • Humans
  • Insecticides (poisoning, toxicity)
  • Male
  • Nervous System Diseases (chemically induced, enzymology, pathology)

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