Protective effect of hydroxyzine and phenylpropanolamine in the challenged allergic nose.

Abstract	Allergic rhinitis patients were challenged with intranasal allergen aerosols after pretreatment with hydroxyzine and phenylpropanolamine, singly and in combination. Hydroxyzine protected against itching, sneezing and hypersecretion but aggravated obstruction. Phenylpropanolamine had a subtle but measurable anti-congestive effect. This model quantitates and confirms the complementary effects of combined antihistamine-decongestant therapy.
Authors	C D Brooks, A Nelson, R Parzyck, M H Maile
Journal	Annals of allergy (Ann Allergy) Vol. 47 Issue 5 Pt 1 Pg. 316-9 (Nov 1981) ISSN: 0003-4738 [Print] United States
PMID	7316247 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References	Hydroxyzine Phenylpropanolamine
Topics	Adult Airway Resistance (drug effects) Drug Therapy, Combination Female Humans Hydroxyzine (therapeutic use) Male Middle Aged Nasal Provocation Tests Phenylpropanolamine (therapeutic use) Pruritus (drug therapy) Rhinitis, Allergic, Seasonal (prevention & control) Sneezing (drug effects)

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