HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Hypotensive action of nifedipine (Ca2+-antagonist) and propranolol in acute trials and its long-term therapy of hypertensive coronary heart disease patients.

Abstract
The hypotensive effect of nifedipine (a Ca2+-antagonist) was studied in acute tests and during the long-term administration of the drug together with propranolol. Nifedipine (10 mg, sublingually) decreased blood pressure from 174/102 to 136/82 mmHg with increase in heart rate and plasma renin activity. The combination of nifedipine (10 mg, sublingually) and propranolol (0.2 mg/Kg body weight, intravenously) decreased blood pressure from 168/104 to 131/86 mmHg with decrease in heart rate and plasma renin activity. Twenty-five hypertensive patients were treated with nifedipine and propranolol (10 mg x 3 to 4/day) together with or without diuretic for long-term. With the combination therapy, blood pressure of Group I (11 hypertensive patients with coronary heart disease) fell from 211/129 to 140/85 mmHg, blood pressure of Group II (9 severe hypertensive patients without coronary heart disease) from 230/137 to 139/84 mmHg, and blood pressure of Group III (5 established hypertension) from 182/107 to 134/83 mmHg. With this treatment regimen, heart rate and plasma renin activity decreased, and abnormal electrocardiographic findings, hypertensive retinopathy, and renal dysfunction were improved. Nifedipine, in combination with propranolol and a diuretic, is considered an effective treatment of hypertension either with or without coronary heart disease.
AuthorsK Aoki, S Kondo, K Sato, K Kato, Y Kawaguchi, A Mochizuki, M Yamamoto
JournalJapanese heart journal (Jpn Heart J) Vol. 22 Issue 4 Pg. 575-84 (Jul 1981) ISSN: 0021-4868 [Print] Japan
PMID7300028 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Pyridines
  • Propranolol
  • Nifedipine
  • Calcium
Topics
  • Antihypertensive Agents (therapeutic use)
  • Blood Pressure (drug effects)
  • Calcium (antagonists & inhibitors)
  • Coronary Disease (drug therapy, physiopathology)
  • Drug Therapy, Combination
  • Humans
  • Hypertension (drug therapy, physiopathology)
  • Male
  • Middle Aged
  • Nifedipine (therapeutic use)
  • Propranolol (therapeutic use)
  • Pyridines (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: