The influence of ICRF-159 and levamisole on the incidence of metastases following local irradiation of a solid tumor.

Abstract

Courses of irradiation consisting of 6000 rad in ten equal fractions over 12 days delivered to KHT sarcomas in mice controlled 55% of the local tumors but 83% of the mice died from metastases. Three strategies to reduce the risk of metastatic spread were tested. The fractionation scheme was changed to deliver the same total dose using a large initial fraction followed by seven equal portions with the same overall time. ICRF-159 was used with the intention of partially synchronizing the tumor growth fraction in a radiosensitive state of the growth cycle and of promoting normalization of the tumor vasculature. Levamisole was used to stimulate the immune system. The combination of ICRF-159 with the eight-fraction radiation course proved to be effective for both increasing local control and decreasing the incidence of metastases. The addition of levamisole did not improve the results obtained with a combination of ICRF-159 and irradiation.

• Authors: D Baker, W Constable, D Elkon, L Rinehart
• Journal: Cancer (Cancer) Vol. 48 Issue 10 Pg. 2179-83 (Nov 15 1981) ISSN: 0008-543X [Print] United States
• PMID: 7296476 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Piperazines
• Levamisole
• Razoxane

Topics

• Animals
• Female
• Levamisole (therapeutic use)
• Mice
• Neoplasm Metastasis
• Neoplasm Recurrence, Local
• Neoplasms (immunology, therapy)
• Neoplasms, Radiation-Induced (etiology, prevention & control)
• Piperazines (therapeutic use)
• Radiotherapy (adverse effects)
• Radiotherapy Dosage
• Razoxane (therapeutic use)
• Risk