Abstract |
The self-administration rates of four groups of eight rats for low dose cocaine (0.1 mg/kg infusion) under free feeding and 80% body weight conditions, with and without a fixed time 1 min (FT-1) food delivery schedule, were compared with those of saline reinforced animals under the same conditions. Results indicated that (1) overall, self-administration rates were significantly greater for cocaine reinforced animals, (2) significantly higher rates of cocaine self-administration occurred in body weight reduced rats and (3) the operation of FT-1 schedule neither significantly enhanced or inhibited drug intake. In the second experiment, schedule and no schedule conditions were reversed for the sixteen 80% body weight, cocaine reinforced rats. Results showed that reversing schedule and no schedule conditions produced no significant change in drug intake. It was concluded that low dose cocaine self-administration is significantly amplified by body weight reduction.
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Authors | M Papasava, T P Oei, G Singer |
Journal | Pharmacology, biochemistry, and behavior
(Pharmacol Biochem Behav)
Vol. 15
Issue 3
Pg. 485-8
(Sep 1981)
ISSN: 0091-3057 [Print] United States |
PMID | 7291250
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Body Weight
- Cocaine
(administration & dosage)
- Eating
- Male
- Rats
- Rats, Inbred Strains
- Self Administration
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