Treatment of dyskeratosis follicularis Darier with the retinoic acid derivative Ro 10-9359 (Tigason).

Abstract

The results of treatment of 29 patients with Darier's disease with the aromatic retinoid Ro 10-9359 are reported. Therapeutic tests for a period of more than 18 months seem to justify its use in Darier's disease. With a modest dose it is possible to keep the symptoms at an acceptable level, i. e., 50% clearing or more without too troublesome side effects. Because of the side effects the dosage must be fixed individually. It is pointed out that with the development of Ro 10-9359, an efficient remedy for Darier's disease has become available for the first time.

• Authors: J V Christiansen, P Holm, R Møller, F Reymann, H Schmidt
• Journal: Dermatologica (Dermatologica) Vol. 163 Issue 2 Pg. 164-8 ( 1981) ISSN: 0011-9075 [Print] Switzerland
• PMID: 7286356 (Publication Type: Journal Article)

Chemical References

• Tretinoin
• Etretinate

Topics

• Adult
• Darier Disease (drug therapy)
• Dose-Response Relationship, Drug
• Etretinate (adverse effects, therapeutic use)
• Female
• Humans
• Male
• Middle Aged
• Tretinoin (analogs & derivatives)