[Single-dose gentamicin treatment and simultaneous localization of urinary-tract infections (author's transl)].

Abstract

Single-dose gentamicin (80--120 mg; Refobacin) can be used successfully to treat significant bacteriuria in women, while at the same time differentiating between upper and lower urinary tract infection. Localization was achieved by demonstrating antibody-carrying bacteria in urine by immunofluorescence. In all 31 women with lower urinary-tract infection so treated urinary sample continued to be bacteria-free when retested one to for weeks later. On the other hand, in 22 of 25 women with renal bacteriuria the original bacteria were repeatedly isolated after treatment. Using single-dose gentamicin and subsequently re-testing urine samples, renal infections in four women were correctly diagnosed in this manner, although the initial immunofluorescence test was negative.

• Authors: Z Hussain, P Burchardt, V Biernat, H Bürger
• Journal: Deutsche medizinische Wochenschrift (1946) (Dtsch Med Wochenschr) Vol. 106 Issue 43 Pg. 1420-3 (Oct 23 1981) ISSN: 0012-0472 [Print] Germany
• Vernacular Title: Einmaltherapie mit Gentamicin und gleichzeitige Lokalisation von Harnwegsinfekten.
• PMID: 7285825 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibodies, Bacterial
• Gentamicins

Topics

• Antibodies, Bacterial (urine)
• Bacteriuria (immunology)
• Female
• Gentamicins (administration & dosage)
• Humans
• Urinary Tract Infections (diagnosis, drug therapy)