Acute glomerular lesions induced by polyvinyl alcohol-bovine serum albumin (PVA-BSA) complex in the rat--a possible mechanism of local immune complex formation.

Abstract

Two types of renal lesions, renal cortical necrosis and acute proliferative glomerular lesions were induced by a single or several intravenous injections of polyvinyl alcohol (PVA)-bovine serum albumin (BSA) complex in Wistar King Aptakeman rats. All animals given a single dose died of renal cortical necrosis within 7 days. Injected PVA-BSA complex was localized in the glomerular capillary lumina in a pattern of thrombosis. All animals given daily injections of a small dose for 5 days developed acute proliferative glomerular lesions accompanied by a significant deposition of IgG, IgM and C3 in the mesangium in which the PVA-BSA complex had been localized. The subsequent deposition of immunoglobulins and complement was suggestive of a possible mechanism of local immune complex formation in the development of the present proliferative glomerular lesions.

• Authors: Y Suzuki
• Journal: The Japanese journal of experimental medicine (Jpn J Exp Med) Vol. 50 Issue 6 Pg. 395-406 (Dec 1980) ISSN: 0021-5031 [Print] Japan
• PMID: 7277783 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigen-Antibody Complex
• Serum Albumin, Bovine
• Polyvinyl Alcohol

Topics

• Acute Disease
• Animals
• Antigen-Antibody Complex (analysis)
• Female
• Glomerulonephritis (immunology)
• Kidney (pathology)
• Kidney Glomerulus (immunology)
• Male
• Platelet Aggregation
• Polyvinyl Alcohol (immunology)
• Proteinuria (immunology)
• Rats
• Rats, Inbred Strains
• Serum Albumin, Bovine (immunology)