Postoperative nausea and vomiting treated with domperidone (r 33812) an open and a double-blind study.

Abstract

The effect of domperidone on postoperative nausea and vomiting was evaluated in two consecutive studies. Fifty-eight patients with postoperative nausea and vomiting were included in an open pilot study and 38 other patients in a double-blind trial. In the first study 4 mg of domperidone was found to be significantly superior to 2 mg, in controlling nausea and vomiting. In the double-blind trial, vomiting recurred significantly later in domperidone than in placebo-treated patients. Side-effects were not seen nor reported in either study.

• Authors: A Stockman, D Caron, J Gallant, A Boghaert
• Journal: Der Anaesthesist (Anaesthesist) Vol. 27 Issue 11 Pg. 540-3 (Nov 1978) ISSN: 0003-2417 [Print] Germany
• PMID: 727428 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antiemetics
• Benzimidazoles
• Piperidines

Topics

• Antiemetics (therapeutic use)
• Benzimidazoles (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Nausea (drug therapy)
• Piperidines (therapeutic use)
• Postoperative Complications
• Vomiting (drug therapy)