Variation in nucleolar organizer activity in lymphocytes of females with adenocarcinoma.

Abstract

With the use of Ag staining and conventional light microscopy, a difference is visualized in the frequency of nucleolar organizer regions between PHA-stimulated lymphocytes from normal females and females with various types of adenocarcinoma. This difference in NOR activity is more pronounced in G chromosome than D chromosomes. It is feasible that rDNA gene activity in PHA-stimulated lymphocytes is augmented in patients with adenocarcinoma due to the presence of plasma mediators arising from cellular malignancies. The NOR regions located on G chromosomes are considered to be more sensitive to these mediators than those on D chromosomes.

• Authors: D M Cheng, T E Denton, S L Liem, C L Elliot
• Journal: Clinical genetics (Clin Genet) Vol. 19 Issue 3 Pg. 145-8 (Mar 1981) ISSN: 0009-9163 [Print] Denmark
• PMID: 7273456 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Ribosomal Proteins
• Silver

Topics

• Adenocarcinoma (genetics)
• Adult
• Aged
• Chromosomes, Human, 13-15
• Chromosomes, Human, 21-22 and Y
• Female
• Genetic Variation
• Humans
• Lymphocytes (pathology)
• Middle Aged
• Nucleolus Organizer Region (pathology)
• Ribosomal Proteins (genetics)
• Silver