Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection.

Abstract

Win 41258-3 (4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1H-pyrazole methane sulfonate) has in vitro and in vivo activity against herpes simplex virus types 1 and 2. In cell culture, a concentration of 2 microgram/ml produced a greater than 50% inhibition of plaque formation of herpes simplex virus type 2, and 3 microgram/ml produced a 100% reduction of herpes simplex virus type 1. Win 41258-3 was effective against herpes simplex virus types 1 and 2 in mouse genital infection after intravaginal administration. Win 41258-3 was administered to mice at 4 h postinfection with solutions containing 1.25, 2.5, 5, or 10% of the compound in saturated tampons. Therapy resulted in a high survival rate (80 to 100%) of treated animals versus 20 to 30% of placebo-treated controls. Win 41258-3 was also effective in guinea pig skin infection produced by herpes simplex virus type 1. Solutions of 2.5, 5, and 10% Win 41258-3, applied to the skin starting 24 h postinfection, resulted in rapid suppression of development of herpetic vesicles and significant reduction of the virus titers in the lesion sites.

• Authors: F Pancic, B A Steinberg, G D Diana, P M Carabateas, W G Gorman, P E Came
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 19 Issue 3 Pg. 470-6 (Mar 1981) ISSN: 0066-4804 [Print] United States
• PMID: 7247370 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Pyrazoles
• Viral Proteins
• Win 41258-3

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Cells, Cultured
• Female
• Genital Diseases, Female (drug therapy)
• Genital Diseases, Male (drug therapy)
• Guinea Pigs
• Herpes Simplex (drug therapy)
• Male
• Mice
• Pyrazoles (therapeutic use)
• Skin Diseases, Infectious (drug therapy)
• Viral Proteins (metabolism)