[Effect of alloxan diabetes on the enzyme activity of the mucous membrane of the small intestine].

Abstract

Experiments on male rats showed that following subcutaneous injection of alloxan in a dose of 15 mg per 100 g of body weight amylolytic, invertase, glycyl-l-tyrosine dipeptidehydrolase activity of the mucosa of the small intestine altered differently. As a result, there occurred a deviation of the enzymatic spectrum from the normal characterized by a sharp increase (with the development of diabetes) of the activity of the carbohydrate hydrolysing enzymes (amylase and invertase) with a simultaneous reduction of the activity of the enzymes participating in protein (dipeptidase) and fat (monglyceridlipase) hydrolysis.

• Authors: K R Rakhimov, B Z Zaripov
• Journal: Problemy endokrinologii (Probl Endokrinol (Mosk)) 1978 Nov-Dec Vol. 24 Issue 6 Pg. 85-9 ISSN: 0375-9660 [Print] Russia (Federation)
• Vernacular Title: Vliianie alloksanovogo diabeta na fermentativnuiu aktivnost' slizistoĭ obolochki tonkoĭ kishki.
• PMID: 724680 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Alloxan
• Monoacylglycerol Lipases
• Amylases
• Sucrase
• Dipeptidases

Topics

• Alloxan (administration & dosage)
• Amylases (metabolism)
• Animals
• Diabetes Mellitus, Experimental (enzymology)
• Dipeptidases (metabolism)
• Intestinal Mucosa (enzymology)
• Male
• Monoacylglycerol Lipases (metabolism)
• Rats
• Sucrase (metabolism)
• Time Factors