Abstract |
A 16 1/2-year-old girl was studied because of ileitis, lack of pubertal development, and primary amenorrhea. She had a 46,XY chromosome constitution in lymphocytes in fibroblasts without structural defects of X or Y. She was H-Y antigen negative. This observation supports the concept of causal heterogeneity of XY gonadal dysgenesis ( Swyer syndrome). Two groups have been established: (1) H-Y antigen-positive forms, which are more common, possibly due to gonad-specific receptor defects (total failure or reduced receptor affinity), (2) H-Y antigen-negative forms possibly due to mutation in the H-Y generating system, either of the structural gene (presumably autosomal) or of a controlling gene (on the sex chromosomes). The H-Y antigen status may be of value in determining which patients are at risk for gonadoblastoma or dysgerminoma.
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Authors | E Passarge, U Wolf |
Journal | American journal of medical genetics
(Am J Med Genet)
Vol. 8
Issue 4
Pg. 437-41
( 1981)
ISSN: 0148-7299 [Print] United States |
PMID | 7246614
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Crohn Disease
(complications, genetics)
- Female
- Genetic Variation
- Gonadal Dysgenesis
(genetics)
- Gonadal Dysgenesis, 46,XY
(complications, genetics)
- H-Y Antigen
(genetics)
- Humans
- Karyotyping
- Lymphocytes
(cytology)
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