The effect of dantrolene sodium in relation to blood levels in spastic patients after prolonged administration.

Abstract

In 25 patients with spasticity, pharmacokinetics and effects of dantrolene sodium were investigated after prolonged administration. A beneficial effect occurred in seven patients. The results were better on 100 mg daily than on a higher daily dose. An increase of the daily dose from 200 to 400 mg was not associated with higher blood levels. Many side effects were noted such as: anorexia, nausea, drowsiness, depression and muscle weakness. From this study we conclude that dantrolene sodium is a muscle relaxant with a weak to moderate effect in patients with spasticity; the effect at doses higher than 200 mg daily is probably poor.

• Authors: W J Meyler, H Bakker, J J Kok, S Agoston, H Wesseling
• Journal: Journal of neurology, neurosurgery, and psychiatry (J Neurol Neurosurg Psychiatry) Vol. 44 Issue 4 Pg. 334-9 (Apr 1981) ISSN: 0022-3050 [Print] England
• PMID: 7241161 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Muscle Relaxants, Central
• Dantrolene

Topics

• Adult
• Aged
• Brain Concussion (drug therapy)
• Dantrolene (therapeutic use)
• Dose-Response Relationship, Drug
• Female
• Humans
• Male
• Middle Aged
• Multiple Sclerosis (drug therapy)
• Muscle Relaxants, Central (therapeutic use)
• Muscle Spasticity (drug therapy)
• Paralysis (drug therapy)
• Spinal Cord Diseases (drug therapy)