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Evolution of lipoprotein patterns in newborns.

Abstract
The plasma levels of total and high-density lipoprotein cholesterol and of the major apolipoproteins (apo B and apo A-I) were studied in 30 newborns, on cord blood and after 7 and 30 days of life. The evolution of these parameters during the first month of life shows that newborns have low LDL cholesterol and apo B levels at birth, which increase drastically during the first week and remain constant between 7 and 30 days. The HDL cholesterol and apo A-I levels are proportionally high at birth and keep increasing slowly up to 30 days. During this period, the cholesterol/apoprotein ratio remains constant in the LDL and HDL class. These data suggest that lipid and apoprotein levels at 7 days are more representative than cord-blood levels and more meaningful for a screening of congenital hypercholesterolemia. The cholesterol/apo B and apo B/apo A-I ratios, which are considered to be better predictive factors for atherosclerosis, should be included as screening parameters.
AuthorsJ P Van Biervliet, R Vercaemst, W De Keersgieter, N Vinaimont, H Caster, M Rosseneu
JournalActa paediatrica Scandinavica (Acta Paediatr Scand) Vol. 69 Issue 5 Pg. 593-6 (Sep 1980) ISSN: 0001-656X [Print] Sweden
PMID7234379 (Publication Type: Journal Article)
Chemical References
  • Apolipoproteins
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Cholesterol
Topics
  • Apolipoproteins (blood)
  • Cholesterol (blood)
  • Humans
  • Hypercholesterolemia (diagnosis)
  • Infant, Newborn
  • Lipoproteins, HDL (blood)
  • Lipoproteins, LDL (blood)
  • Mass Screening (methods)
  • Time Factors

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