HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Significance of experimental models in neurooncology.

Abstract
Three models are induced for the production of brain tumors: Carcinogenic viruses, topically applied carcinogenic hydrocarbons and so-called resorptive carcinogens, mostly alkylating substances. The usefulness of these models for questions in human neurooncology depends upon similarity relation between model and original, i.e. the human brain tumor, both regarding the induction mode and the morphological result. In the last years the model with resorptive carcinogens has been broadly used. This model is suitable for questions concerning the mechanisms of action of carcinogenic substances and the formal pathogenesis of brain tumors. It seems less appropriate for other investigations: The growth behavior and its possible influence may be better studied with standardized tumor models. Such derived models are described in this paper and their usefulness for investigations especially concerning the chemotherapy of brain tumors is discussed.
AuthorsH D Mennel
JournalNeurosurgical review (Neurosurg Rev) Vol. 3 Issue 2 Pg. 129-37 ( 1980) ISSN: 0344-5607 [Print] Germany
PMID7231684 (Publication Type: Journal Article)
Chemical References
  • Carcinogens
Topics
  • Animals
  • Brain Neoplasms (etiology)
  • Carcinogens (administration & dosage)
  • Cricetinae
  • Disease Models, Animal
  • Dogs
  • Mice
  • Neoplasm Transplantation
  • Neoplasms, Experimental (etiology, pathology)
  • Nervous System Neoplasms (etiology, pathology)
  • Rabbits
  • Rats
  • Research Design
  • Tumor Virus Infections (etiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: