Abstract |
Six alkylarylnitrosoureas were checked for induction of chromosome aberrations and SCEs in Chinese hamster V79-E cells and compared with MNU, ENU and nitrosocarbaryl. All agents show a DNA-damaging activity. Studies of the dependence of aberration frequency on recovery time revealed drastic differences within this group of closely related substances.
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Authors | R Thust, J Mendel, H Schwarz, R Warzok |
Journal | IARC scientific publications
(IARC Sci Publ)
Issue 31
Pg. 797-802
( 1980)
ISSN: 0300-5038 [Print] France |
PMID | 7228300
(Publication Type: Journal Article)
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Chemical References |
- Carcinogens
- Nitrosourea Compounds
|
Topics |
- Animals
- Carcinogens
- Cell Line
- Chromosome Aberrations
- Cricetinae
- Cricetulus
- Kinetics
- Nitrosourea Compounds
(pharmacology)
- Sister Chromatid Exchange
(drug effects)
- Structure-Activity Relationship
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