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Clastogenicity and aberration kinetics of some alkylarylnitrosoureas in Chinese hamster V79-E cells.

Abstract
Six alkylarylnitrosoureas were checked for induction of chromosome aberrations and SCEs in Chinese hamster V79-E cells and compared with MNU, ENU and nitrosocarbaryl. All agents show a DNA-damaging activity. Studies of the dependence of aberration frequency on recovery time revealed drastic differences within this group of closely related substances.
AuthorsR Thust, J Mendel, H Schwarz, R Warzok
JournalIARC scientific publications (IARC Sci Publ) Issue 31 Pg. 797-802 ( 1980) ISSN: 0300-5038 [Print] France
PMID7228300 (Publication Type: Journal Article)
Chemical References
  • Carcinogens
  • Nitrosourea Compounds
Topics
  • Animals
  • Carcinogens
  • Cell Line
  • Chromosome Aberrations
  • Cricetinae
  • Cricetulus
  • Kinetics
  • Nitrosourea Compounds (pharmacology)
  • Sister Chromatid Exchange (drug effects)
  • Structure-Activity Relationship

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