Groups of 40 male and 40 female C57BL/6 mice were maintained for 75-80 weeks on meal form diets containing
aspirin,
phenacetin and
caffeine either singly or in combination. The maximum daily doses of
phenacetin alone and the APC combination were approximately one-half of their previously determined respective oral LD50's. Mild, nonprogressive histopathologic changes of the urinary tract were noted with these changes first evident in animals given the highest dose of
phenacetin.
Sulfhemoglobinemia was also induced in all groups of animals given
phenacetin alone or in combination indicating that toxic doses were administered oral LD50's. Mild, nonprogressive histopathologic changes of the urinary tract were noted with these changes first evident in animals given the highest dose of
phenacetin.
Sulfhemoglobinemia was also induced in all groups of animals given
phenacetin alone or in combination indicating that toxic doses were administered oral LD50's. Mild, nonprogressive histopathologic changes of the urinary tract were noted with these changes first evident in animals given the highest dose of
phenacetin.
Sulfhemoglobinemia was also induced in all groups of animals given
phenacetin alone or in combination indicating that toxic doses were administered. Under the conditions of this study, evidence of
carcinogens was not demonstrated for any of the drugs given alone or in combination.