HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Experimental allergic neuritis induced by galactocerebroside.

Abstract
Experimental allergic neuritis (EAN), an animal model of human demyelinative neuritis, was induced by sensitization with galactocerebroside, a glycolipid hapten common in central and peripheral nervous system myelin. Between two months and one year after the initial sensitization, 11 of 24 rabbits immunized repeatedly with bovine brain galactocerebroside (GC) in complete Freund's adjuvant developed a neurological disorder manifested by flaccid quadriparesis, limb hypesthesia, and respiratory paralysis. Seventeen of 20 autopsied rabbits, including all those with clinical illness, had small multiple perivascular foci of demyelinative lesions in roots, dorsal root ganglia, proximal peripheral nerves adjacent to ganglia, and, less frequently, in distal nerves. No change was found in the central nervous system. Demyelination started around venules, with splitting and vesiculation of the outer myelin sheaths of adjacent fibers, and later progressed to form confluent lesions. The lesions were associated with infiltration of phagocytic mononuclear cells, mostly macrophages, which insinuated themselves between myelin lamellae, phagocytized myelin, and subsequently denuded axons. Perivenular infiltration of small lymphocytes, comparable to that seen in whole nerve- induced EAN, was not encountered. The distribution of demyelinative lesions seems to correspond to areas known to have a defective blood-nerve barrier.
AuthorsT Saida, K Saida, D H Silberberg, M J Brown
JournalAnnals of neurology (Ann Neurol) Vol. 9 Suppl Pg. 87-101 ( 1981) ISSN: 0364-5134 [Print] United States
PMID7224618 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Cerebrosides
  • Galactosylceramides
Topics
  • Animals
  • Autoimmune Diseases (immunology)
  • Cerebrosides (immunology)
  • Demyelinating Diseases (immunology)
  • Disease Models, Animal
  • Galactosylceramides (immunology)
  • Myelin Sheath (immunology)
  • Nerve Fibers, Myelinated (ultrastructure)
  • Peripheral Nerves (pathology)
  • Polyradiculoneuropathy (immunology, pathology)
  • Rabbits
  • Spinal Nerve Roots (pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: