[Human sex skin fibroblast cultures : a useful tool for diagnosis of male pseudohermaphroditism due to target organ unresponsiveness to androgens (author's transl)].

Abstract

Sex skin fibroblast cultures were reported to constitute a fair model for studying male pseudohermaphroditism (MPH) due to target organ unresponsiveness to androgens. Using this technique, we made the diagnosis of MPH due to steroid 5 alpha-reductase deficiency, complete or partial androgen insensitivity. This technique gave the opportunity to describe an unstable form of 5 alpha-reductase and a thermolability of androgen receptors responsible for MPH. This method permitted a better understanding of disorders of male sex differentiation.

• Authors: C Sultan, C J Migeon
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) 1980 Jul-Aug Vol. 41 Issue 4 Pg. 305-10 ISSN: 0003-4266 [Print] France
• Vernacular Title: La culture de fibroblastes : moyen d'étude des anomalies de l'action cellulaire des androgènes au cours du pseudo-hermaphrodisme mäle.
• PMID: 7212637 (Publication Type: English Abstract, Journal Article)

Chemical References

• Androgens

Topics

• Androgens (physiology)
• Cells, Cultured
• Disorders of Sex Development (diagnosis, metabolism, physiopathology)
• Fibroblasts (pathology)
• Genitalia, Male (cytology)
• Humans
• Male