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Vancomycin therapy for serious staphylococcal infections in chronic hemodialysis patients.

Abstract
Vancomycin therapy during 7 episodes of serious staphylococcal infections in chronic hemodialysis patients was monitored by a sensitive bioassay technique. One gm of vancomycin was given during dialysis at a mean dosage interval of 7 days for a mean duration of 48 days. Serum peak and trough vancomycin levels were monitored during therapy. Accumulation of vancomycin occurred in 1 patient on prolonged therapy; progressive rising through levels required a reduction in vancomycin dosage. Pre and post-dialysis vancomycin levels in one patient were unchanged. Vancomycin was effective in eradication of all staphylococcal infections and bacteremias. Three A-V shunt infections required surgical revision; 2 A-V fistula infections were salvaged with vancomycin therapy alone. We conclude that 1 gm vancomycin every 7 days is an effective regimen for serious staphylococcal infections in chronic hemodialysis patients. Monitoring of vancomycin levels insures maintenance of adequate levels and prevents toxic accumulation.
AuthorsM H Bierman, C A Needham-Walker, M Hammeke, J D Egan
JournalJournal of dialysis (J Dial) Vol. 4 Issue 4 Pg. 179-84 ( 1980) ISSN: 0362-8558 [Print] United States
PMID7204716 (Publication Type: Journal Article)
Chemical References
  • Vancomycin
Topics
  • Aged
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Kidney Failure, Chronic (complications, therapy)
  • Male
  • Middle Aged
  • Renal Dialysis
  • Staphylococcal Infections (complications, drug therapy)
  • Vancomycin (blood, therapeutic use)

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