Alterations in drug induced catalepsy and post-decapitation convulsions following brain and spinal cord depletion of norepinephrine by the neurotoxin DSP-4.

Abstract

The effects of central norepinephrine depletion produced by DSP-4 on drug-induced catalepsy and pot-decapitation convulsions were examined in the rat. Haloperidol-induced catalepsy was potentiated in DSP-4 treated rats, while arecoline-induced catalepsy was attenuated. Furthermore, post-decapitation convulsions were eliminated in DSP-4 treated animals. DSP-4 may prove to be a useful tool with which to investigate the behavioral consequences of damage to the locus coeruleus noradrenergic system.

• Authors: K E Asin, D Wirtshafter, H C Fibiger
• Journal: Life sciences (Life Sci) Vol. 30 Issue 18 Pg. 1531-6 (May 03 1982) ISSN: 0024-3205 [Print] Netherlands
• PMID: 7200562 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Amines
• Benzylamines
• Neurotoxins
• Arecoline
• Haloperidol
• DSP 4
• Norepinephrine

Topics

• Amines (pharmacology)
• Animals
• Arecoline (pharmacology)
• Benzylamines (pharmacology)
• Brain (drug effects)
• Catalepsy (chemically induced, metabolism)
• Drug Interactions
• Haloperidol (pharmacology)
• Humans
• Male
• Neurotoxins (pharmacology)
• Norepinephrine (metabolism)
• Rats
• Rats, Inbred Strains
• Seizures (metabolism)
• Spinal Cord (drug effects)