[Hyperoncotic hemodilution in the ewe asa model of therapy in EPH gestosis (author's transl)].

Abstract

Hyperoncotic hemodilution is proposed as a new therapeutic procedure in EPH-gestosis for improvement of uterine blood flow. By infusion of human albumin solutions in acute experiments on pregnant Merino sheep the effects of altered maternofetal colloid osmotic pressure gradients were investigated. The proposed hemodilution treatment improved uterine blood flow without a theoretically apprehended and undesired fetal hemoconcentration. An absolute indication for hypervolemic EPH-gestosis is suggested in accordance with modern knowledge of the pathophysiology of microcirculation. Isovolemic hemodilution is proposed to be of potential value in cases of EPH-gestosis with normovolemia, hypertension, intrauterine fetal growth retardation or other symptoms of placental insufficiency, at least as a subject to further studies.

• Authors: R Schröck, W Heimisch, K Gebhardt, N Mendler
• Journal: Zeitschrift fur Geburtshilfe und Perinatologie (Z Geburtshilfe Perinatol) Vol. 185 Issue 3 Pg. 168-77 (Jun 1981) ISSN: 0300-967X [Print] Germany
• Vernacular Title: Hyperonkotische Hämodilution beim schwangeren Schaf als Therapiemodell der EPH-Gestose.
• PMID: 7196653 (Publication Type: English Abstract, Journal Article)

Chemical References

• Serum Albumin

Topics

• Amniotic Fluid (analysis)
• Animals
• Blood Pressure
• Cardiac Output
• Female
• Heart Rate
• Hematocrit
• Hemodilution (methods)
• Osmotic Pressure
• Pre-Eclampsia (therapy)
• Pregnancy
• Serum Albumin (administration & dosage)
• Sheep
• Uterus (blood supply)