Time-dependency of neurohypophyseal peptide attenuation of puromycin amnesia in mice.

Abstract

[Ile3, Arg8]vasopressin (arginine-vasotocin), as well as the C-terminal tripeptides of the neurohypophyseal hormones arginine and lysine vasopressin, Pro-Arg-Gly-NH2 and Pro-Lys-Gly-NH2, were protective against puromycin-induced amnesia in mice when administered 24h before training. The N-protected tripeptide derivative, Z-Pro-Lys-Gly-NH2, was effective when given 5 days before training. The effectiveness of all peptides to attenuate puromycin-induced amnesia decreased as the interval between training and peptide treatment increased, indicating that the peptides influence memory processes, rather than general arousal. Z-Pro-Lys-Gly-NH2 was active at 24h after training, when the other peptides were no longer effective. Although it seems clear that neurohypophyseal hormones per se can attenuate puromycin-induced amnesia, these results are in line with the possibility that some portion of hormone action may be mediated via formation of longer-lived hormone fragments in the CNS.

• Authors: R Walter, P L Hoffman, J B Flexner, L B Flexner
• Journal: International journal of peptide and protein research (Int J Pept Protein Res) Vol. 16 Issue 5 Pg. 482-6 (Nov 1980) ISSN: 0367-8377 [Print] Denmark
• PMID: 7194322 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Neurophysins
• Oligopeptides
• Vasopressins
• Arginine Vasopressin
• prolyl-arginyl-glycinamide
• Puromycin
• prolyl-lysyl-glycinamide
• Arginine

Topics

• Amnesia (chemically induced)
• Animals
• Arginine (pharmacology)
• Arginine Vasopressin (pharmacology)
• Humans
• Hypothalamus (metabolism)
• Memory (drug effects)
• Mice
• Neurophysins (pharmacology)
• Oligopeptides (pharmacology)
• Puromycin
• Time Factors
• Vasopressins (pharmacology)