Comparison of the antigenicity of melanotic and amelanotic melanoma cells after the release of surface glycoproteins by trypsin.

Abstract

The antigenicity of isolated cells of malanotic and amelanotic melanomas after the release of surface glycoproteins by trypsin was studied by the migration inhibition test. It has been found that after treatment with trypsin the antgenicity of melanotic melanoma cells increased, while the amelanotic melanoma cells lost their ability to inhibit macrophage migration.

• Authors: K Kozłowska, B Zurawska-Czupa, A Kostulak
• Journal: Archivum immunologiae et therapiae experimentalis (Arch Immunol Ther Exp (Warsz)) Vol. 28 Issue 4 Pg. 641-4 ( 1980) ISSN: 0004-069X [Print] Switzerland
• PMID: 7192976 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Neoplasm
• Glycoproteins
• Membrane Proteins
• Trypsin

Topics

• Animals
• Antigens, Neoplasm (immunology)
• Cell Membrane (metabolism)
• Cell Migration Inhibition
• Cells, Cultured
• Cricetinae
• Glycoproteins (metabolism)
• Macrophages (immunology)
• Male
• Melanoma (immunology, pathology)
• Membrane Proteins (metabolism)
• Mesocricetus
• Neoplasms, Experimental (pathology)
• Skin Neoplasms (immunology, pathology)
• Trypsin (pharmacology)