Abstract |
Two tests (the frequency of dominant lethal mutations at different stages of spermatogenesis and the yield of chromosome aberrations in bone marrow cells) were used to investigate mutagenisity of N-nitrosomorpholine (NM), N-nitroso-N- methylurea (NMU) and cyclophosphamide (CTX). The drugs were injected once intraperitoneally to male mice (F1 of CBA X C57BL) at doses of NM--50 mg/kg; NMU--50 mg/kg; CTX--50, 100, 200 and 300 mg/kg. It was established that NM was not mutagenic in the mouse as measured by these two tests. NMU was a weak mutagen at the stated exposure, since there was only slight increase in the frequency of dominant lethal mutations in late spermatids and spermatogonia, and also a low yield of chromosome aberrations in bone marrow cells was induced. CTX had a strong mutagenic effect on postmeiotic stages of spermatogenesis and in bone marrow cells.
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Authors | L K Ramaĭia, M D Pomerantseva, G A Vilkina |
Journal | Genetika
(Genetika)
Vol. 16
Issue 6
Pg. 1036-43
( 1980)
ISSN: 0016-6758 [Print] Russia (Federation) |
Vernacular Title | Sravnitel'naia éffektivnost' ispol'zovaniia raznykh testov dlia opredeleniia mutagennosti nekotorykh faktorov u mlekopitaiushchikh. Soobshchenie I. Chastota dominantnykh letal'nykh mutatsiĭ i khromosomnykh aberratsiĭ v kletkakh kostnogo mozga myshi, indutsirovannykh N-nitrozomorfolinom, N-nitrozo-N-metilmichevinoĭ i tsiklofosfamidom. |
PMID | 7192667
(Publication Type: Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Morpholines
- Nitrosamines
- Nitrosourea Compounds
- N-nitrosomorpholine
- Methylnitrosourea
- Cyclophosphamide
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Topics |
- Animals
- Bone Marrow
(ultrastructure)
- Chromosome Aberrations
- Cyclophosphamide
(toxicity)
- Female
- Fetal Death
- Genes, Dominant
- Genes, Lethal
- Hybridization, Genetic
- Male
- Methylnitrosourea
(toxicity)
- Mice
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Morpholines
(toxicity)
- Mutagenicity Tests
- Nitrosamines
(toxicity)
- Nitrosourea Compounds
(toxicity)
- Pregnancy
- Spermatozoa
(ultrastructure)
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