Abstract |
This preliminary study was undertaken to identify the combined efficacy of perfluorochemicals (Fluosol-43) and a chemotherapeutic agent ( BCNU) in a rat brain tumor model. The brain tumor model was produced by the intracerebral transplantation of C6 rat glioma cells. Fluosol-43 plus BCNU in an oxygen environment produced a significant prolongation of mean survival time compared to that of BCNU treatment alone. Perfluorochemicals (Fluosol-43) seem to have some synergistic effect on BCNU chemotherapy for this brain tumor model.
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Authors | T Kokunai, K Kuwamura |
Journal | Surgical neurology
(Surg Neurol)
Vol. 18
Issue 4
Pg. 258-61
(Oct 1982)
ISSN: 0090-3019 [Print] United States |
PMID | 7179085
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Combinations
- Fluorocarbons
- Hydroxyethyl Starch Derivatives
- Plasma Substitutes
- glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination
- Carmustine
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Topics |
- Animals
- Brain
(pathology)
- Brain Neoplasms
(drug therapy, pathology)
- Carmustine
(therapeutic use)
- Drug Combinations
(administration & dosage)
- Drug Therapy, Combination
- Fluorocarbons
(administration & dosage)
- Glioma
(drug therapy, pathology)
- Hydroxyethyl Starch Derivatives
- Necrosis
- Neoplasm Transplantation
- Neoplasms, Experimental
(drug therapy)
- Plasma Substitutes
(administration & dosage)
- Rats
- Rats, Inbred Strains
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