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Effect of perfluorochemicals on BCNU chemotherapy: preliminary study in a rat brain tumor model.

Abstract
This preliminary study was undertaken to identify the combined efficacy of perfluorochemicals (Fluosol-43) and a chemotherapeutic agent (BCNU) in a rat brain tumor model. The brain tumor model was produced by the intracerebral transplantation of C6 rat glioma cells. Fluosol-43 plus BCNU in an oxygen environment produced a significant prolongation of mean survival time compared to that of BCNU treatment alone. Perfluorochemicals (Fluosol-43) seem to have some synergistic effect on BCNU chemotherapy for this brain tumor model.
AuthorsT Kokunai, K Kuwamura
JournalSurgical neurology (Surg Neurol) Vol. 18 Issue 4 Pg. 258-61 (Oct 1982) ISSN: 0090-3019 [Print] United States
PMID7179085 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Combinations
  • Fluorocarbons
  • Hydroxyethyl Starch Derivatives
  • Plasma Substitutes
  • glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination
  • Carmustine
Topics
  • Animals
  • Brain (pathology)
  • Brain Neoplasms (drug therapy, pathology)
  • Carmustine (therapeutic use)
  • Drug Combinations (administration & dosage)
  • Drug Therapy, Combination
  • Fluorocarbons (administration & dosage)
  • Glioma (drug therapy, pathology)
  • Hydroxyethyl Starch Derivatives
  • Necrosis
  • Neoplasm Transplantation
  • Neoplasms, Experimental (drug therapy)
  • Plasma Substitutes (administration & dosage)
  • Rats
  • Rats, Inbred Strains

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