Indomethacin by intravenous infusion in ureteral colic. A multicentre study.

Abstract

In a multicentre study the analgetic effect of indomethacin in ureteral colic was analyzed. Indomethacin, which inhibits the synthesis of prostaglandin, was given by intravenous infusion in a dose of 50 mg. The study comprised 198 patients with 252 attacks of ureteral colic. Satisfactory relief of pain was obtained in 212 attacks (84%). No serious side effects of indomethacin were observed. The pain recurred within four hours in only 15 patients (7%), in 12 of them during a diagnostic intravenous pyelography. The relief of pain may be explained by reduced glomerular filtration pressure and/or diminished urinary excretion, causing rapid fall in the renal pelvic pressure and in the tension of the pelvi-ureteral wall. A low extracellular volume of fluid in a patient with ureteral colic may be essential for analgetic action of indomethacin.

• Authors: J G Sjödin, D Holmlund
• Journal: Scandinavian journal of urology and nephrology (Scand J Urol Nephrol) Vol. 16 Issue 3 Pg. 221-5 ( 1982) ISSN: 0036-5599 [Print] England
• PMID: 7163787 (Publication Type: Journal Article)

Chemical References

• Indomethacin

Topics

• Adult
• Aged
• Blood Pressure (drug effects)
• Colic (drug therapy)
• Female
• Humans
• Indomethacin (administration & dosage, adverse effects, therapeutic use)
• Infusions, Parenteral
• Kidney Pelvis (physiopathology)
• Male
• Middle Aged
• Pressure
• Ureteral Diseases (drug therapy)