Effect of trimethyltin on chemically-induced seizures.

Abstract

The effect of trimethyltin (TMT; 4.26 mg/kg i.p.), at 1 and 14 h following administration, on chemically-induced seizures in mice is reported. At 1 h following administration, TMT decreased seizure responsiveness and protected animals from bicuculline, isonicotinic acid hydrazide (INH) and pentylenetetrazol (PTZ) induced seizures. At 14 h following administration, TMT provided little protection against bicuculline, INH or PTZ induced seizures. Only slight decreases in seizure responsiveness were observed with strychnine induced seizures at either 1 or 14 h. By 16 h following administration, animals exhibited spontaneous tremors and convulsions. The results indicate that TMT exerts a biphasic effect on central nervous system excitability.

• Authors: S V Doctor, L G Costa, S D Murphy
• Journal: Toxicology letters (Toxicol Lett) Vol. 13 Issue 3-4 Pg. 217-23 (Oct 1982) ISSN: 0378-4274 [Print] Netherlands
• PMID: 7147265 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticonvulsants
• Trialkyltin Compounds
• Trimethyltin Compounds
• Strychnine
• Isoniazid
• Pentylenetetrazole
• Bicuculline

Topics

• Animals
• Anticonvulsants
• Bicuculline (pharmacology)
• Isoniazid (pharmacology)
• Male
• Mice
• Pentylenetetrazole (pharmacology)
• Seizures (chemically induced, physiopathology)
• Strychnine (pharmacology)
• Time Factors
• Trialkyltin Compounds (pharmacology)
• Trimethyltin Compounds (pharmacology)