[Triamterene and renal calculi].

Abstract

The authors report the detailed analysis of 4 calculi containing triamterene observed between 1979 and 1981. The composition of drug layers is almost the same in the 4 calculi and shows a mixture of triamterene (estimated at 35% of iatrogenic components) and 7 metabolites among them p-hydroxy-triamterene (5-10%) and mainly p-hydroxytriamterene estersulfate (40-55%). The authors hypothesize a metabolic or physicochemical relation between triamterene and uric acid which are frequently associated in these calculi that represent 0.4% of all lithiasis. An estimated 150 to 200 calculi with triamterene are probably eliminated though not detected every year in France. The interest of a fine analysis of calculi by appropriate physical methods, such as infrared spectrometry, is emphasized.

• Authors: M Daudon, M F Protat, R J Réveillaud
• Journal: Nephrologie (Nephrologie) Vol. 3 Issue 3 Pg. 119-23 ( 1982) ISSN: 0250-4960 [Print] Switzerland
• Vernacular Title: Triamtérène et lithiases rénales.
• PMID: 7144994 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Triamterene

Topics

• Adult
• Aged
• Chromatography, Thin Layer
• Humans
• Kidney Calculi (chemically induced, metabolism)
• Male
• Middle Aged
• Spectrophotometry, Infrared
• Triamterene (adverse effects, analysis)