Fifty years ago, in 1932, skeletal fluorosis was discovered as an
occupational disease in
cryolite workers in Copenhagen, Denmark. Following the initial reports, new cases were identified in other industries, such as the production of
aluminum and
superphosphate fertilizer. In light cases of fluorosis, the bone changes are often associated with nonspecific joint and muscle pains, but the disease may be entirely asymptomatic. The
fluoride-induced
osteosclerosis seems to be reversible, but the long-term significance of
fluoride accumulation in the body is not known. Family cases of
dental fluorosis have been occurred in long-term residents near
fluoride-emitting industries, and in hot areas with high, natural
fluoride levels in the
drinking water. Skeletal fluorosis has only played a minor role in the discussion concerning
fluoridation of
drinking water, however. Changing and increasing uses of
fluorides have led to a renewed interest in this
occupational disease.