Progressive neurological disorder associated with obstructive jaundice and vitamin E deficiency.

Abstract

A ten-year-old girl had obstructive jaundice in the newborn period which persisted for 4 years despite choledochojejunostomy at 6 weeks. From the age of 6 years she developed a progressive neurological syndrome characterized mainly by dysarthria and ataxia. A causal relationship with her profound vitamin E deficiency seemed likely. Treatment with vitamin E over a 2 1/2 year period appeared to arrest the progression of the neurological deficit and subsequent increase in dosage produced some improvement in her ataxia.

• Authors: B W Lloyd, V Dubowitz
• Journal: Neuropediatrics (Neuropediatrics) Vol. 13 Issue 3 Pg. 155-7 (Aug 1982) ISSN: 0174-304X [Print] Germany
• PMID: 7133335 (Publication Type: Case Reports, Journal Article)

Topics

• Ataxia (complications)
• Child
• Cholestasis (complications)
• Dysarthria (complications)
• Female
• Humans
• Infant, Newborn
• Jaundice, Neonatal (complications)
• Speech Disorders (complications)
• Syndrome
• Vitamin E Deficiency (complications)