[Studies on the kinetics of nitrofurantoin (Nifurantin) in normal pregnancy, gestoses, pyelonephritis and labor (author's transl)].

Abstract

After oral administration of 300 mg of nitrofurantoin (Nifurantin) to various groups of pregnants, to women in labour and nonpregnant women the blood level and renal excretion of nitrofurantoin were investigated. We stated that gravidity, pyelonephritis and EPH-gestosis did not alter neither the renal excretion nor the blood level. In contrast to this during labour the renal elimination of nitrofurantoin was diminished and the blood concentration was enhanced. The biotransformation of nitrofurantoin seems not to be changed by pregnancy.

• Authors: H Nöschel, S Schröder, K H Eichhorn, G Peiker
• Journal: Die Pharmazie (Pharmazie) Vol. 37 Issue 3 Pg. 204-5 (Mar 1982) ISSN: 0031-7144 [Print] Germany
• Vernacular Title: Untersuchungen zur Kinetik von Nitrofurantoin (Nifurantin) in der normalen Schwangerschaft, bei Gestosen, Pyelonephritis und unter der Geburt.
• PMID: 7100243 (Publication Type: English Abstract, Journal Article)

Chemical References

• Nitrofurantoin

Topics

• Biotransformation
• Female
• Humans
• Kinetics
• Labor, Obstetric
• Nitrofurantoin (metabolism)
• Pre-Eclampsia (metabolism)
• Pregnancy
• Pregnancy Complications (metabolism)
• Pregnancy Complications, Infectious (metabolism)
• Pyelonephritis (metabolism)