Abstract |
Quantitative structure-activity relationships (QSAR) were derived for a number of 2,6-mono- and disubstituted purines. The derived equations relate the anticancer activity in murine Adenocarcinoma CA755 to the molar refractivity of substituents at position 2 and electron-withdrawing effects of substituents at position 6. A QSAR was also derived for the acute toxicity (LD50) of substituents at position 6. The results suggest that toxicity is relatively independent of the nature of the substituent.
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Authors | Z Neiman, F R Quinn |
Journal | Journal of pharmaceutical sciences
(J Pharm Sci)
Vol. 71
Issue 6
Pg. 618-20
(Jun 1982)
ISSN: 0022-3549 [Print] United States |
PMID | 7097521
(Publication Type: Journal Article)
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Chemical References |
- Antineoplastic Agents
- Purines
|
Topics |
- Adenocarcinoma
(drug therapy)
- Animals
- Antineoplastic Agents
- Chemical Phenomena
- Chemistry, Physical
- Mice
- Neoplasms, Experimental
(drug therapy)
- Purines
(pharmacology, toxicity)
- Structure-Activity Relationship
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