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Quantitative structure-activity relationships of purines II: Prediction of activity against adenocarcinoma CA755 and toxicity in mice.

Abstract
Quantitative structure-activity relationships (QSAR) were derived for a number of 2,6-mono- and disubstituted purines. The derived equations relate the anticancer activity in murine Adenocarcinoma CA755 to the molar refractivity of substituents at position 2 and electron-withdrawing effects of substituents at position 6. A QSAR was also derived for the acute toxicity (LD50) of substituents at position 6. The results suggest that toxicity is relatively independent of the nature of the substituent.
AuthorsZ Neiman, F R Quinn
JournalJournal of pharmaceutical sciences (J Pharm Sci) Vol. 71 Issue 6 Pg. 618-20 (Jun 1982) ISSN: 0022-3549 [Print] United States
PMID7097521 (Publication Type: Journal Article)
Chemical References
  • Antineoplastic Agents
  • Purines
Topics
  • Adenocarcinoma (drug therapy)
  • Animals
  • Antineoplastic Agents
  • Chemical Phenomena
  • Chemistry, Physical
  • Mice
  • Neoplasms, Experimental (drug therapy)
  • Purines (pharmacology, toxicity)
  • Structure-Activity Relationship

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