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Antitumor activity of 1-acyloxymethyl derivatives of 5-fluorouracil against L1210 leukemia.

Abstract
Antitumor activity of 15 1-acyloxymethyl derivatives of 5-fluorouracil was examined by both intraperitoneal injection and oral administration in L1210 leukemia system. Therapeutic ratio for dodecanoyloxymethyl derivative by intraperitoneal injection was 23 which was greater than that for 5-fluorouracil (11). On the other hand, undecanoyloxymethyl derivative of 5-fluorouracil showed the highest therapeutic ratio (5.8) when administered orally which was greater than that for 5-fluorouracil (1.9) and 1-(2-tetrahydrofuryl)-5-fluorouracil (1.0).
AuthorsA Hoshi, M Inomata, F Kanzawa, M Iigo, K Kuretani
JournalJournal of pharmacobio-dynamics (J Pharmacobiodyn) Vol. 5 Issue 3 Pg. 208-12 (Mar 1982) ISSN: 0386-846X [Print] Japan
PMID7097489 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antineoplastic Agents
  • Fluorouracil
Topics
  • Administration, Oral
  • Animals
  • Antineoplastic Agents
  • Fluorouracil (analogs & derivatives, pharmacology)
  • Injections, Intraperitoneal
  • Leukemia L1210 (drug therapy)
  • Male
  • Mice
  • Mice, Inbred Strains

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