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Antibiotic loaded plaster of Paris pellets: an in vitro study of a possible method of local antibiotic therapy in bone infection.

Abstract
Plaster of Paris is an effective ancillary treatment in the surgery of infected cavities in bone. It is well tolerated and spontaneously absorbed over a period of weeks to months, being replaced by bone of normal architecture. It effectively obliterates much of the dead space, leaving little room for hematoma formation. It would appear logical to treat local infection, especially involving rigid walled cavities, by a locally diffused antibiotic. When incorporated into plaster of Paris pellets, two antibiotics, Fucidin and gentamicin, are capable of prolonged local release in bacteriocidal concentrations. On the basis of in vitro observations on bacterial cultures, it is proposed that antibiotic-plaster of Paris pellets might be a simple adjuvant technique to good surgical debridement in the treatment of bone infection. Plaster of Paris has the practical advantage over acrylic cement beads containing antibiotics in that it is resorbed and would not need a subsequent operation to be moved.
AuthorsD Mackey, A Varlet, D Debeaumont
JournalClinical orthopaedics and related research (Clin Orthop Relat Res) Issue 167 Pg. 263-8 (Jul 1982) ISSN: 0009-921X [Print] United States
PMID7094471 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Anti-Bacterial Agents
  • Gentamicins
  • Methylmethacrylates
  • Methylmethacrylate
  • Fusidic Acid
  • Lincomycin
  • Cefazolin
  • Calcium Sulfate
Topics
  • Anti-Bacterial Agents (administration & dosage)
  • Calcium Sulfate
  • Cefazolin (administration & dosage)
  • Fusidic Acid (administration & dosage)
  • Gentamicins (administration & dosage)
  • Humans
  • In Vitro Techniques
  • Lincomycin (administration & dosage)
  • Methylmethacrylate
  • Methylmethacrylates
  • Osteomyelitis (drug therapy)
  • Staphylococcus aureus (drug effects)

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