Penetration of tobramycin sulphate into the human eye.

Abstract	Tobramycin sulphate, a new aminoglycoside antibiotic, was injected intramuscularly (80 and 100 mg) and subconjunctivally (10 mg) into patients, and the concentrations of the drug in serum and aqueous humour were determined 1 hour after the injection by an agar wall diffusion plate method. The intramuscular administration of tobramycin produced insignificant and non-inhibitory concentrations in the aqueous humour, while therapeutically effective levels of the antibiotic appeared in the aqueous after subconjunctival administrationof tobramycin (mean: 18.9 microgram/ml). These data suggest that tobramycin sulphate may be of value in the treatment of ocular infections.
Authors	A Petounis, G Papapanos, C Karageorgiou-Makromihelaki
Journal	The British journal of ophthalmology (Br J Ophthalmol) Vol. 62 Issue 9 Pg. 660-2 (Sep 1978) ISSN: 0007-1161 [Print] England
PMID	708683 (Publication Type: Journal Article)
Chemical References	Anti-Bacterial Agents Tobramycin
Topics	Aged Anti-Bacterial Agents (metabolism) Aqueous Humor (metabolism) Conjunctiva Humans Injections, Intramuscular Middle Aged Tobramycin (administration & dosage, blood, metabolism)

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