Abstract |
Tobramycin sulphate, a new aminoglycoside antibiotic, was injected intramuscularly (80 and 100 mg) and subconjunctivally (10 mg) into patients, and the concentrations of the drug in serum and aqueous humour were determined 1 hour after the injection by an agar wall diffusion plate method. The intramuscular administration of tobramycin produced insignificant and non-inhibitory concentrations in the aqueous humour, while therapeutically effective levels of the antibiotic appeared in the aqueous after subconjunctival administrationof tobramycin (mean: 18.9 microgram/ml). These data suggest that tobramycin sulphate may be of value in the treatment of ocular infections.
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Authors | A Petounis, G Papapanos, C Karageorgiou-Makromihelaki |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 62
Issue 9
Pg. 660-2
(Sep 1978)
ISSN: 0007-1161 [Print] England |
PMID | 708683
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Tobramycin
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Topics |
- Aged
- Anti-Bacterial Agents
(metabolism)
- Aqueous Humor
(metabolism)
- Conjunctiva
- Humans
- Injections, Intramuscular
- Middle Aged
- Tobramycin
(administration & dosage, blood, metabolism)
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