Dose- and time-response relationships of triethylenemelamine-induced chromosomal aberrations in rat bone marrow cells.

Abstract

Groups of 18 male Sprague-Dawley rats were administered single i.p. doses of 0.00, 0.125, 0.25 or 0.50 mg/kg of triethylenemelamine (TEM). 6 rats per treatment group were killed 6, 24 or 48 h after dosing, and bone marrow cells were collected and prepared for cytogenetic analysis. Under the present conditions, 0.25 mg/kg with sampling of bone marrow cells 24 h after treatment appeared to represent optimal conditions for using TEM as a positive control agent in the rat in vivo cytogenetic assay as described.

• Authors: B S Levine, E Pergament, K Driscoll
• Journal: Toxicology letters (Toxicol Lett) Vol. 10 Issue 2-3 Pg. 281-5 (Feb 1982) ISSN: 0378-4274 [Print] Netherlands
• PMID: 7080098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Triethylenemelamine

Topics

• Animals
• Bone Marrow (drug effects, ultrastructure)
• Chromosome Aberrations
• Dose-Response Relationship, Drug
• Male
• Rats
• Rats, Inbred Strains
• Time Factors
• Triethylenemelamine (toxicity)