Prophylaxis of radiation dermatitis with a topical cortisone cream.

Nineteen cancer patients receiving radiation therapy to the head, neck, chest wall, or abdomen were evaluated in a double-blind study to determine the effectiveness of 0.2% hydrocortisone valerate vs. placebo in reducing acute radiation dermatitis. Patients applied hydrocortisone valerate to one-half of the irradiate area and the placebo to the other half beginning two weeks after the initiation of radiotherapy and continuing until three weeks after completion. Left and right sides were scored each week with respect to erythema, dry desquamation, moist desquamation, ulceration, and the duration and intensity of symptoms such as soreness, burning, and itching. No statistically significant difference was found between the 0.2% hydrocortisone valerate and the placebo in the acute skin response or the symptoms of radiation dermatitis. The patients were evaluated three months following radiotherapy for evidence of skin atrophy. There were no differences found between hydrocortisone valerate and the placebo with respect to the late effects of radiation therapy.
AuthorsM E Potera, D P Lookingbill, J A Stryker
JournalRadiology (Radiology) Vol. 143 Issue 3 Pg. 775-7 (Jun 1982) ISSN: 0033-8419 [Print] United States
PMID7079509 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Placebos
  • Hydrocortisone
  • Administration, Topical
  • Anti-Inflammatory Agents (therapeutic use)
  • Double-Blind Method
  • Humans
  • Hydrocortisone
  • Placebos
  • Radiodermatitis (prevention & control)
  • Radiotherapy (adverse effects)
  • Skin (radiation effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: