Abstract |
Bone histology, bone mineral content, and calcium absorption were evaluated in 10 patients with primary biliary cirrhosis and osteopenia, before and after 1 yr of treatment with oral 25-hydroxycholecalciferol. Before treatment, quantitative histomorphometric analysis of full-thickness iliac crest bone biopsy specimens with double- tetracycline labeling demonstrated that 9 of 10 patients had osteoporosis. None had osteomalacia. Fasting intestinal calcium absorption correlated well with trabecular bone volume (r = 0.85). Bone mineral content measured by 125I-photon absorption was low in 6 of 10 patients, and it correlated poorly with iliac crest trabecular bone volume. After 1 yr of treatment with oral 25-hydroxyvitamin D3, bone mineral content fell in all 8 patients who were restudied. Iliac crest trabecular bone volume increased in 3 patients, 2 of whom had the greatest pretreatment impairment in calcium absorption, but fell in 5. Bone fractures continued to occur in 3 of 5 patients who were alive after 1 yr and developed for the first time in a sixth patient. We conclude that 25-hydroxyvitamin D3 is ineffective in reversing the bone thinning in the majority of primary biliary cirrhosis patients, but it may be helpful in a few selected patients.
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Authors | D S Matloff, M M Kaplan, R M Neer, M J Goldberg, W Bitman, H J Wolfe |
Journal | Gastroenterology
(Gastroenterology)
Vol. 83
Issue 1 Pt 1
Pg. 97-102
(Jul 1982)
ISSN: 0016-5085 [Print] United States |
PMID | 7075948
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Hydroxycholecalciferols
- Calcifediol
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Topics |
- Adult
- Bone and Bones
(diagnostic imaging, metabolism, pathology)
- Calcifediol
- Female
- Humans
- Hydroxycholecalciferols
(therapeutic use)
- Liver Cirrhosis, Biliary
(complications)
- Male
- Middle Aged
- Osteoporosis
(diagnostic imaging, drug therapy, etiology, metabolism)
- Radiography
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