Solar urticaria: treatment with PUVA and mediator inhibitors.

Abstract

Several therapeutic regimes for solar urticaria were evaluated. A short course of PUVA therapy produced a marked increase in the minimal dose of radiation required to produce urticaria in the six patients treated. This objective evidence of improvement was supported by the patients' reports of greatly increased tolerance to sun-exposure. Chlorpheniramine, an antihistamine, produced a slight increase in the minimal dose of radiation necessary to produce urticaria but its effectiveness was limited by side-effects. Indomethacin, an inhibitor of prostaglandin synthetase, produced no beneficial effect.

• Authors: J A Parrish, K F Jaenicke, W L Morison, K Momtaz, C Shea
• Journal: The British journal of dermatology (Br J Dermatol) Vol. 106 Issue 5 Pg. 575-80 (May 1982) ISSN: 0007-0963 [Print] England
• PMID: 7073982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Chlorpheniramine
• Indomethacin

Topics

• Adolescent
• Adult
• Chlorpheniramine (therapeutic use)
• Drug Therapy, Combination
• Female
• Humans
• Indomethacin (therapeutic use)
• Male
• Middle Aged
• PUVA Therapy
• Photochemotherapy
• Sunlight
• Urticaria (drug therapy, etiology)