Placental transfer of 14C-hexoprenaline.

Abstract

The placental transfer of a single intravenous injection of 14C-hexoprenaline was studied in eight pregnant New Zealand white rabbits. Maternal and fetal blood was sampled intermittently for 60 minutes after the injection. An initial rapid decrease in the levels of 14C-hexoprenaline in maternal blood was followed by a second slower phase, whereas fetal levels remained insignificant. The conclusion, therefore, is that the rapid improvement in fetal heart rate after the administration of a single maternal intravenous injection of hexoprenaline in the treatment of fetal distress is due to the action on the uterus and/or on maternal cardiovascular function, and not to direct stimulation of the fetus.

• Authors: J Lipshitz, K Broyles, W D Whybrew, R A Ahokas, G D Anderson
• Journal: American journal of obstetrics and gynecology (Am J Obstet Gynecol) Vol. 142 Issue 3 Pg. 313-5 (Feb 01 1982) ISSN: 0002-9378 [Print] United States
• PMID: 7065021 (Publication Type: Journal Article)

Chemical References

• Carbon Radioisotopes
• Phenethylamines
• Hexoprenaline

Topics

• Animals
• Carbon Radioisotopes
• Female
• Fetal Blood (analysis)
• Fetal Distress (prevention & control)
• Hexoprenaline (blood, therapeutic use)
• Maternal-Fetal Exchange
• Phenethylamines (blood)
• Placenta (metabolism)
• Pregnancy
• Rabbits