Histamine synthesis, imidazole dipeptides, and wound healing.

Abstract

The relationships among anserine (beta-alanyl-1-methyl-L-histidine), carnosine (beta-alanyl-L-histidine), free histidine, and histamine metabolism were examined in rats wounded by dorsal skin incision. Following wounding, rats were treated with either a histamine liberator (compound 48/80) or a histidine decarboxylase inhibitor (4-imidazolyl-3-amino-2-butanone). The liberator greatly enhanced wounded skin-breaking strength and collagen deposition at the wound site, while the histidine decarboxylase inhibitor reduced skin-breaking strength and collagen deposition. In the second experiment of this study, histamine or histidine treatment was shown to prevent trauma-induced reductions of tissue carnosine but was less effective in ameliorating tissue anserine loss. The results illustrate an interaction between imidazole dipeptides and stress and suggest that carnosine acts as a histidine reserve in relation to histamine synthesis during trauma.

• Authors: D W Fitzpatrick, H Fisher
• Journal: Surgery (Surgery) Vol. 91 Issue 4 Pg. 430-4 (Apr 1982) ISSN: 0039-6060 [Print] United States
• PMID: 7064098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Butanones
• Dipeptides
• Imidazoles
• 4-imidazolyl-3-amino-2-butanone
• p-Methoxy-N-methylphenethylamine
• Histidine
• Histamine
• Collagen
• Histidine Decarboxylase

Topics

• Animals
• Butanones (pharmacology)
• Collagen (biosynthesis)
• Dipeptides (metabolism)
• Female
• Femoral Fractures (metabolism)
• Histamine (biosynthesis)
• Histidine (metabolism)
• Histidine Decarboxylase (antagonists & inhibitors)
• Imidazoles (pharmacology)
• Male
• Muscles (metabolism)
• Rats
• Rats, Inbred Strains
• Skin (metabolism)
• Tensile Strength (drug effects)
• Wound Healing (drug effects)
• p-Methoxy-N-methylphenethylamine (pharmacology)