Reduction in opiate activation after chronic electroconvulsive shock--possible role for endorphins in the behavioral effects of convulsive shock treatment.

Group-housed adult male Sprague-Dawley rats were given a series of 4 exposures to electroconvulsive shock therapy or equivalent handling without shock (sham treatment). Twenty-four hours after the final treatment the rats were given vehicle or one of two doses of morphine intraperitoneally, and motor activity was assessed by remote sensing for 60 min. A significant shift of the normal dose-response curve towards the right was seen after electroshock. This may point to cross-tolerance between electroshock and opiates upon this behavioral measure. The results are consistent with the hypothesis that endorphins may mediate certain aspects of electroshock.
AuthorsR J Katz, K Schmaltz
JournalNeuroscience letters (Neurosci Lett) Vol. 19 Issue 1 Pg. 85-8 (Aug 1980) ISSN: 0304-3940 [Print] Ireland
PMID7052517 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Endorphins
  • Morphine
  • Animals
  • Brain (physiology)
  • Drug Tolerance
  • Electroconvulsive Therapy
  • Endorphins (physiology)
  • Models, Neurological
  • Morphine (pharmacology)
  • Motor Activity (drug effects)
  • Rats
  • Rats, Inbred Strains

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