Preoperative intraparietal (intra-incisional) cefoxitin in abdominal surgery.

Abstract

The effect of preoperative intraparietal (intra-incisional) injection of cefoxitin along the site of the intended incision on the incidence of wound infection has been investigated by a randomized prospective study of 181 consecutive patients undergoing abdominal surgery. A significant reduction in wound infection was evident in the cefoxitin-treated group (4.4 per cent) when compared with controls (16.7 per cent) (chi 2 = 6; P = 0.02). Administration of antibiotic by this route did not delay wound healing or produce any undesirable sequelae.

• Authors: T V Taylor, W S Walker, R C Mason, J Richmond, D Lee
• Journal: The British journal of surgery (Br J Surg) Vol. 69 Issue 8 Pg. 461-2 (Aug 1982) ISSN: 0007-1323 [Print] England
• PMID: 7049308 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Cefoxitin

Topics

• Abdomen (surgery)
• Adult
• Aged
• Cefoxitin (administration & dosage, therapeutic use)
• Clinical Trials as Topic
• Female
• Humans
• Injections, Subcutaneous
• Male
• Middle Aged
• Preoperative Care
• Surgical Wound Infection (microbiology, prevention & control)