Pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin in experimental Escherichia coli meningitis.

Abstract

The pharmacokinetics and bacteriological efficacy of N-formimidoyl thienamycin were determined in rabbits infected with Escherichia coli K1. After a single intravenous dose of 25 mg/kg, a peak N-formimidoyl thienamycin concentration in cerebrospinal fluid (CSF) of 2.5 micrograms/ml was attained at 45 min. The penetration into CSF was calculated to be 31%. In animals that received continuous intravenous infusions of the drug for 9 h, the mean CSF concentration was 8.2 microgram/ml, and the CSF bactericidal titers against the E. coli K1 strain were from 1:16 to 1:32. This infusion produced a reduction in the numbers of E. coli in the CSF of 4 log10 colony-forming units per ml. N-Formimidoyl thienamycin might prove to be useful for therapy of meningitis caused by E. coli and other susceptible bacteria.

• Authors: P Patamasucon, G H McCracken Jr
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 21 Issue 3 Pg. 390-2 (Mar 1982) ISSN: 0066-4804 [Print] United States
• PMID: 7049073 (Publication Type: Journal Article)

Chemical References

• Anti-Bacterial Agents
• Lactams
• Imipenem

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage, metabolism, therapeutic use)
• Escherichia coli Infections (drug therapy)
• Imipenem
• Infusions, Parenteral
• Injections, Intravenous
• Kinetics
• Lactams (administration & dosage, metabolism, therapeutic use)
• Male
• Meningitis (drug therapy)
• Rabbits